Vitamin A: Essential for Eyes, Nerves, Pregnancy, Immunity System

Vitamin A:

Vitamin A was identified as a necessary growth factor in 1915 and was the first vitamin to be discovered.

It is obtained from food in a combination of two different forms: as pre-formed vitamin A and as pro-vitamin A, which the body can convert to vitamin A as necessary.

Pre-formed vitamin A, often in the form of retinal or retinol, is found in foods of animal origin; pro-vitamin A, of which beta-carotene is the best known form, is found in orange, yellow and dark green vegetables and fruits.

Both forms are fat soluble.

Benefits of Vitamin A

  • Eyes - Vitamin A is essential for eyes to function effectively.

    It is involved in the growth and repair of the eye and in the production of a chemical called visual purple, which helps in night vision.

  • Epithelial Cells - Vitamin A is involved in the growth and repair of epithelial cells.

    These cells cover the internal and external surfaces of the body and are found in the skin, lungs, developing teeth, inner ear, cornea of the eye, sex organs, glands and their ducts, gums, nose, cervix and other areas.

    This growth and maintenance role is vital for many bodily functions.

    For example, the good health of the digestive tract lining is important in protecting against ulcers and maintenance of the lining of the vagina and uterus is important in fertility.

  • Pregnancy - Vitamin A is necessary in pregnancy for the development of the embryo.
  • Nerves - Vitamin A is involved in the production of membranes and myelin, which coats the nerves.
  • Glands and Hormones - Vitamin A plays a role in the maintenance of the adrenal gland and synthesis of certain hormones such as thyroid hormone.
  • The Immunity System - Vitamin A is known as "the anti-infective vitamin" as it is vital for the development of the body’s natural defenses.

    It stimulates and enhances many immune functions.

    This immune enhancing function promotes healing of tissues and increases resistance to infection.

    Adequate vitamin A intake, either from diet or supplements, is very important, especially for children. Many studies have found that vitamin A supplementation reduces the risk of infectious diseases in areas where vitamin A deficiency is widespread.

    A recent research review of several studies found that adequate vitamin A intake in children resulted in many health benefits.

    Children in developing countries are often at high risk of vitamin A deficiency.

    In developed countries, ensuring adequate vitamin A intake is particularly important for immune support.

  • Growth and Bone Formation - Vitamin A is necessary for growth and the formation of bones and teeth, collagen synthesis, cartilage synthesis and wound healing.
  • Antiviral Activity - Laboratory experiments have shown vitamin A to have antiviral activity.

Absorption of Vitamin A

The presence of fat and bile in the intestines is necessary for vitamin A absorption.

Around 80 to 90 % of vitamin A in the diet is absorbed although this is reduced in older people and those who have trouble absorbing fat, such as those who suffer from pancreatitis, celiac disease and cystic fibrosis, who may run the risk of vitamin A deficiency.

Vitamin A is joined to fatty acids in the intestinal lining, combined with other substances and transported to the liver, which stores 90% of the body’s vitamin A.

Vitamin A deficiency

Vitamin A deficiency is relatively rare in developed countries and is usually limited to those who have absorption difficulties, liver disease or who drink a lot of alcohol.

Vitamin A deficiency is common in alcoholics and contributes to some of the disorders of alcoholism, such as night blindness, skin problems, cirrhosis of the liver and susceptibility to infections.

Vitamin A deficiency symptoms

  • Eyes - One of the first symptoms of deficiency is night blindness due to lack of visual purple.

    Prolonged deficiency leads to xerophthalmia, a condition in which eyes become dry, ulcers appear on the cornea, the eyelids become swollen and sticky and which eventually leads to blindness.

    Vitamin A deficiency is the leading preventable cause of blindness in developing countries.

  • Skin - Prolonged deficiency leads to thickened dry skin which is prone to infections.

    Small hardened bumps of a protein known as keratin may develop around the hair follicles.

  • Growth - Deficiency causes growth retardation, weight loss, diarrhea, thickening of bone shafts, congenital malformations, impaired hearing, taste and smell, wasting of testicles and reduced sperm count.

    Inadequate vitamin A intake may lead to improper tooth formation in children and to gum disease.

  • Immune System - Epithelial surfaces are adversely affected by vitamin A deficiency, causing increased susceptibility to skin and respiratory infections.

    Immune cells and antibody functions are also affected which may lead to an increase in pre-cancerous cells in the epithelial tissues of the mouth, throat and lungs.

  • Thyroid Gland - A deficiency of vitamin A can contribute to lower levels of active thyroid hormone with symptoms of low body temperature, depression, difficulty in losing weight, headaches and lethargy.

Therapeutic Uses

Skin Disorders - The vitamin A derivatives etretinate and isotretinoin are used topically to treat psoriasis. These compounds inhibit the formation of some of the toxic compounds which may be responsible for the high rate of cell division causing the scaly build up on the skin.

Other Uses

Vitamin A eye drops have been used to treat dry eyes.

Creams containing vitamin A have been used to heal wounds in patients taking corticosteroid drugs.

Interactions

  • Vitamin E and zinc are necessary for vitamin A metabolism, including absorption, transport and release from the liver.
  • Vitamin E may protect against some of the effects of excess vitamin A
  • Vitamin A is necessary for calcium metabolism in the formation of healthy bones and teeth.
  • Vitamin A absorption is reduced by mineral oil laxatives, which bind it.
  • Antacids, the anti-gout drug colchicine, and the cholesterol reducing drug cholestyramine inhibit vitamin A absorption.
  • Alcohol irritates the digestive tract and inhibits the absorption of vitamin A while also depleting the body’s tissue stores.

Effects of excess vitamin A

Symptoms of getting too much vitamin A are irritability, fatigue, lethargy, stomach pain, painful joints, severe throbbing headache, insomnia and restlessness, night sweats, loss of body hair, brittle nails, and a bug-eyed expression (exophthalmus)

Cautions

Pre-formed vitamin A supplements in doses of more than 3000 mg RE should not be taken by women who may become pregnant.

Pro-vitamin A or beta-carotene are safe for pregnant women.

Vitamin A supplements should not be taken with isotretinoin or etretinate for skin disease or in cases of impaired liver or kidney function. If vitamin A supplements are taken with large amounts of alcohol, liver damage may occur.

Broad spectrum antibiotics should not be taken with high doses of vitamin A.

Sources of Vitamin A

  • Vitamin A is present in leafy green vegetables
  • Vitamin A is present in yellow fruits and vegetables
  • Vitamin A is present in the liver oils of the cod and other fish
  • Vitamin A is present in milk, cheese, butter, and egg yolk

Symmetry Products with Vitamin A: NutraPack, Mega Juice, Fruit-a-Mins, Premium Plus, Aloe Plus, Extreme Fuel, Extreme Igniton & Recovery, Ultra Vitality, Future Star, Symmetry Natural Facial Care System

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