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Niacin Deficiency Causes a Disease Called Pellagra
Niacin deficiency. - A deficiency of niacin affects every cell, especially where there is rapid cell turnover, such as the skin, gastrointestinal (GI) tract, and nervous system.
- A deficiency of Niacin causes a disease called pellagra.
Pellagra is the disease of the three Ds, diarrhea, dermatitis, and dementia. - Some characteristics of pellagra include decreased energy and problems maintaining the integrity of the skin and intestinal tract.
Symptoms include weakness and fatigue, anorexia, indigestion, and skin irregularities. These can progress to canker sores, nausea, vomiting, and diarrhea. Reduced stomach acid production will contribute to mal-absorption of a number of nutrients including fat and fat-soluble vitamins. The initial neurological symptoms are irritability and insomnia with headaches. The symptoms of niacin deficiency or pellagra can progress to extreme anxiety, depression and psychosis. - Niacin, in the form of nicotinic acid, can produce a niacin flush.
This flush is evident as a redness, warmth, and itching to the skin. This typically happens when the dosage is 50 mg or higher. The flush is the result of vasodilation. While some find this feeling uncomfortable, it is harmless.
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