Pellagra - Niacin Deficiency

Pellagra is a disease caused from niacin deficiency

Niacin acts in the breakdown and use of all major foods.

As a result, niacin deficiency affects every cell, especially where there is rapid cell turnover, such as the skin, gastrointestinal (GI) tract, and nervous system.

Pellagra is the disease of the three Ds: diarrhea, dermatitis, and dementia.

• Some characteristics of pellagra include decreased energy and problems maintaining the integrity of the skin and intestinal tract.
• The initial neurological symptoms are irritability and insomnia with headaches.

  The symptoms can progress to extreme anxiety, depression and psychosis.

• Other symptoms include weakness and fatigue, anorexia, indigestion, and skin irregularities.
• These can progress to canker sores, nausea, vomiting, and diarrhea.
• Reduced stomach acid production will contribute to mal-absorption of a number of nutrients including fat and fat-soluble vitamins.

Niacin, in the form of nicotinic acid, can produce a Niacin flush.

This is a redness, warmth, and itching to the skin.

This typically happens when the dosage is 50 mg or higher.

The flush is the result of vasodilation.

While some find this feeling uncomfortable, it is harmless.

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